Q: Is the ‘Entourage Effect’ a proven phenomenon?
A: In the last 20 years there’s been a great deal of research and clinical trial information that corroborates the synergy between plant components. There are concrete medical examples of the increased analgesic effects of CBD found in full-spectrum hemp.
Q: Since the CBD entourage effect is well established, what about the cannabinoid-terpene entourage effect?
A: Terpenoids are essential oil components of cannabis that are very pharmacologically active, even in small concentrations. For example, alpha-pinene, found in high concentrations in some hemp varietals, is an acetylcholine inhibitor--which means it inhibits the enzyme that breaks down acetylcholine, a neurotransmitter in the brain involved with increased memory and reduction in depression. Studies in advanced neuropsychological testing show interactions between cannabinoids and various terpenoids as it relates to memory and clarity of thought.
A: The use of full spectrum is generally favoured over isolates. This is because with pure, highly processed, single cannabinoids, there can be a biphasic dose response curve. For example: a low dose doesn’t necessarily treat pain, a middle dose does, but at a higher dose you lose the therapeutic benefits. When a full-spectrum extract is used, you can get a more predictable dose response curve that’s a steady slope "upward" with a much larger therapeutic window to treat pain. With isolates you get a steep drop-off at higher and lower doses making accurate dosing much more difficult.
Q: Is full-spectrum CBD more clinically effective, even at lower doses?
A: A published study compared the doses of CBD isolates that were necessary to treat severe seizures disorders as compared to how much CBD was necessary when it was supplied as a full-spectrum extract. What the reserachers
discovered was that compared to pure isolates, full-spectrum CBD (with all the natural plant components) could be dosed at less than twenty-two percent (22%) of what was needed with purified CBD to achieve the equivalent benefits with fewer side effects and drug-to-drug interactions with a full-spectrum extract. #cbd #cbdsky #cbdoil #cbdfullspectrumoil #cbdoil #cbdisolate #isolate #entourageffect #organic #nongmo #gf